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TREATMENT OF SMALL CELL LUNG CANCER WITH A PARP INHIBITOR.

Abstract

Described are methods of treatment of a small cell lung cancer subject expressing Schlafen-11 (SLFN 11 ) with a Poly (ADP-ribose) polymerases (PARP) inhibitor or a pharmaceutically acceptable salt thereof. Specifically, the method comprising detecting SLFN 11 in a tumor cell sample from the subject, and administering effective amount of a PARP inhibitor, such as talazoparib or the tosylate salt of talazoparib, to the subject. :.Se describen métodos para el tratamiento de un sujeto con cáncer de pulmón de células pequeñas que expresa Schlafen-11 (SLFN 11) con un inhibidor de poli(ADP-ribosa) polimerasas (PARP) o una sal farmacéuticamente aceptable del mismo. Específicamente, el método comprende la detección de SLFN 11 en una muestra de células tumorales del sujeto, y la administración al sujeto de una cantidad eficaz de un inhibidor de PARP, tal como talazoparib o la sal de tosilato de talazoparib.

Original Text (This is the original text for your reference.)

Described are methods of treatment of a small cell lung cancer subject expressing Schlafen-11 (SLFN 11 ) with a Poly (ADP-ribose) polymerases (PARP) inhibitor or a pharmaceutically acceptable salt thereof. Specifically, the method comprising detecting SLFN 11 in a tumor cell sample from the subject, and administering effective amount of a PARP inhibitor, such as talazoparib or the tosylate salt of talazoparib, to the subject. :.Se describen métodos para el tratamiento de un sujeto con cáncer de pulmón de células pequeñas que expresa Schlafen-11 (SLFN 11) con un inhibidor de poli(ADP-ribosa) polimerasas (PARP) o una sal farmacéuticamente aceptable del mismo. Específicamente, el método comprende la detección de SLFN 11 en una muestra de células tumorales del sujeto, y la administración al sujeto de una cantidad eficaz de un inhibidor de PARP, tal como talazoparib o la sal de tosilato de talazoparib.

Inventor: Ying FENG;Leonard E. POST;Yuqiao SHEN;Yuanbin RU;Evelyn WANG;Karen YU

Application number: MX2018005071

Publication number: MX2018005071A

Filing date: 2016-10-26

Publication date: 2020-05-25

Type of Patent: A

Source: IKCEST

Disclaimer: The translated content is provided by third-party translation service providers, and IKCEST shall not assume any responsibility for the accuracy and legality of the content.
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