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Biomedical Optics Express

Biomedical Optics Express

Archives Papers: 1,186
The Optical Society of America
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Enhancing sparse-view photoacoustic tomography with combined virtually parallel projecting and spatially adaptive filtering
YihanWang; TongLu; JiaoLi; WenboWan; WenjuanMa; LiminZhang; ZhongxingZhou; JingyingJiang; HuijuanZhao; FengGao;
Keywords:Angiography;Computed tomography;Image quality;Magnetic resonance imaging;Medical imaging;Small animal imaging;
Abstracts:To fully realize the potential of photoacoustic tomography (PAT) in preclinical and clinical applications, rapid measurements and robust reconstructions are needed. Sparse-view measurements have been adopted effectively to accelerate the data acquisition. However, since the reconstruction from the ... [Biomed. Opt. Express 9, 4569-4587 (2018)]
Recent advances in infrared laser lithotripsy [Invited]
NathanielM.Fried;
Keywords:High power fiber lasers;High power lasers;Laser beams;Laser energy;Q switched lasers;Solid state lasers;
Abstracts:The flashlamp-pumped, solid-state, pulsed, mid-infrared, holmium:YAG laser (λ = 2120 nm) has been the clinical gold standard laser for lithotripsy for over the past two decades. However, while the holmium laser is the dominant laser technology in ureteroscopy because it efficiently ablates ... [Biomed. Opt. Express 9, 4552-4568 (2018)]
Multiple surface segmentation using convolution neural nets: application to retinal layer segmentation in OCT images
AbhayShah; LeixinZhou; MichaelD.Abrámoff; XiaodongWu;
Keywords:Feature extraction;Image analysis;Image processing;Low coherence interferometry;Medical image processing;Optical surfaces;
Abstracts:Automated segmentation of object boundaries or surfaces is crucial for quantitative image analysis in numerous biomedical applications. For example, retinal surfaces in optical coherence tomography (OCT) images play a vital role in the diagnosis and management of retinal diseases. Recently, graph ... [Biomed. Opt. Express 9, 4509-4526 (2018)]
Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening
KristinaA.Hallam; EleanorM.Donnelly; AndreiB.Karpiouk; RobinK.Hartman; StanislavY.Emelianov;
Keywords:Confocal laser scanning microscopy;Dynamic light scattering;Imaging techniques;Laser energy;Laser irradiation;Laser light;
Abstracts:A major obstacle in the monitoring and treatment of neurological diseases is the blood brain barrier (BBB), a semipermeable barrier that prevents the delivery of many therapeutics and imaging contrast agents to the brain. In this work, we explored the possibility of laser-activated perfluorocarbon ... [Biomed. Opt. Express 9, 4527-4538 (2018)]
Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study
YumieOno; KimiyaEsaki; YutaTakahashi; MikieNakabayashi; MasashiIchinose; KijoonLee;
Keywords:Absorption coefficient;Blood;Light intensity;Near infrared spectroscopy;Photon counting;Reflection coefficient;
Abstracts:We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the ... [Biomed. Opt. Express 9, 4539-4551 (2018)]
Modified wavelength scanning interferometry for simultaneous tomography and topography of the cornea with Fourier domain optical coherence tomography
SusobhanDas; Chih-HaoLiu; ManmohanSingh; MichaelD.Twa; KirillV.Larin;
Keywords:Coherence imaging;Imaging techniques;Low coherence interferometry;Medical imaging;Nanopositioning equipment;Surface roughness measurement;
Abstracts:Visual acuity is dependent on corneal shape and size. A minor variation in surface geometry can cause a deformation of corneal geometry, which affects its optical performance. In this work we demonstrate an algorithm for the simultaneous measurement of corneal tomography and topography with a ... [Biomed. Opt. Express 9, 4443-4458 (2018)]
Rapid and in situ optical detection of trace lithium in tissues
IrfanAhmed; JingweiYang; AlanWingLunLaw; FrancisA.M.Manno; RafayAhmed; YanpengZhang; CondonLau;
Keywords:Analytical techniques;Emission;Laser beams;Laser induced breakdown;Laser induced breakdown spectroscopy;Optical detection;
Abstracts:Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer’s disease. However, the therapeutic mechanisms are not well characterized due to limitations in detecting lithium in organs and cells. This limits the ability to improve ... [Biomed. Opt. Express 9, 4459-4471 (2018)]
Ultrasound-assisted photothermal therapy and real-time treatment monitoring
HaeminKim; GyuwonJo; JinHoChang;
Keywords:Laser beams;Laser energy;Laser irradiation;Light wavelength;Nd:YAG lasers;X ray computed tomography;
Abstracts:Photothermal therapy (PTT) has the capability for selective treatment, in which light delivered to the target is converted into heat and subsequently causes coagulative necrosis. However, optical scattering in biological media limits light penetration, thus reducing therapeutic efficacy. Here, we ... [Biomed. Opt. Express 9, 4472-4480 (2018)]
Robust layer segmentation of esophageal OCT images based on graph search using edge-enhanced weights
MengGan; CongWang; TingYang; NaYang; MiaoZhang; WuYuan; XingdeLi; LirongWang;
Keywords:Anisotropic diffusion;Edge detection;Image processing;Image quality;Medical imaging;Three dimensional imaging;
Abstracts:Automatic segmentation of esophageal layers in OCT images is crucial for studying esophageal diseases and computer-assisted diagnosis. This work aims to improve the current techniques to increase the accuracy and robustness for esophageal OCT image segmentation. A two-step edge-enhanced graph ... [Biomed. Opt. Express 9, 4481-4495 (2018)]
Dual-type hyperspectral microscopic imaging for the identification and analysis of intestinal fungi
SifanLin; XiaolinBi; SiqiZhu; HaoYin; ZhenLi; ChenqiangChen;
Keywords:Fourier transform infrared spectroscopy;Hyperspectral imaging;Image processing;Image processing algorithms;Imaging systems;Ionization spectroscopy;
Abstracts:A method based on a dual-type (transmission and fluorescence) hyperspectral microscopic image system was developed to identify species of intestinal fungi. Living fungi are difficult to identify via transmission spectra or fluorescence spectra alone. We propose an identification method based on ... [Biomed. Opt. Express 9, 4496-4508 (2018)]
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