Endothelial NO-synthase (eNOS) gene allelic polymorphism in 221 patients with acute coronary syndrome and in 83 practically healthy people was determined. It was shown that interrelations of normal homozygotes, heterozygotes and pathologic homozygotes in T/C promoter polymorphism analysis accout 48%, 36% and 16% correspondingly (in control--48%, 46%, 6%; P < 0.05 by chi2-test); in G894 --> T polymorphism ofexon 7 analysis--34%, 58%, 8% (in control--29%, 67%, 4%; P > 0.05), and in determination of 4a/4b polymorphism of intron 4--64.5%, 31% and 4.5% (in control--62.5%, 32.5%, 5%; P > 0.05). Obtained data show that eNOS C/C promoter variant is a risk factor of acute coronary syndrome in Ukrainian population.

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4a4b polymorphism enos cc promoter variant homozygotes enos gene allelic polymorphism tc promoter polymorphism analysis

V E, Dosenko Ia M, Luta? V Iu, Zagori? A N, Parkhomenko A A, Mo?benko,.[Frequencies of allelic polymorphism of endothelial NO-synthase gene in patients with acute coronary syndrome in Ukrainian population].. 39 (2),49-54.

V E, Dosenko Ia M, Luta? V Iu, Zagori? A N, Parkhomenko A A, Mo?benko,"[Frequencies of allelic polymorphism of endothelial NO-synthase gene in patients with acute coronary syndrome in Ukrainian population]." 39

V E, Dosenko Ia M, Luta? V Iu, Zagori? A N, Parkhomenko A A, Mo?benko,"[Frequencies of allelic polymorphism of endothelial NO-synthase gene in patients with acute coronary syndrome in Ukrainian population]."