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Zeitschrift für Naturforschung. C, Journal of biosciences | Vol.47, Issue.11-12 | | Pages 893-7

Different effect of dGTP on 2'-deoxyadenosine metabolism in mitochondria and cytosol.

J, Greger K, Fabianowska-Majewska

Abstract

Two enzymes participating in 2'-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated. Mitochondrial and cytosol dAdoK are separate proteins, while ADA from both subcellular fractions possesses similar physical properties. dGTP, a competitive inhibitor of mitochondrial dAdoK, inhibits cytosol ADA in a mixed way but activates mitochondrial ADA and cytosol dAdoK. A possible effect of dGTP on dAdo metabolism in mitochondria and cytosol is discussed.

Original Text (This is the original text for your reference.)

Different effect of dGTP on 2'-deoxyadenosine metabolism in mitochondria and cytosol.

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Keywords

2deoxyadenosine dado metabolism dado kinase adenosine deaminase ada

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J, Greger K, Fabianowska-Majewska,.Different effect of dGTP on 2'-deoxyadenosine metabolism in mitochondria and cytosol.. 47 (11-12),893-7.

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