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Journal of the American Pharmaceutical Association | Vol.45, Issue.6 | | Pages 411-413
Derivatives of arylpolycarbamic acids of pharmacologic interest
Urethanes and urea derivatives prepared by reaction of arylpolyisocyanates with various tertiary-amino alcohols and N,N-disubstituted-alkylenediamines, respectively, have been prepared for pharmacologic investigation. The polyquaternary salts are of particular interest in view of their structural relationship to such neuro-muscular-blocking agents as succinylcholine and hexamethylene bis(carbamoylcholine).
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Derivatives of arylpolycarbamic acids of pharmacologic interest
Urethanes and urea derivatives prepared by reaction of arylpolyisocyanates with various tertiary-amino alcohols and N,N-disubstituted-alkylenediamines, respectively, have been prepared for pharmacologic investigation. The polyquaternary salts are of particular interest in view of their structural relationship to such neuro-muscular-blocking agents as succinylcholine and hexamethylene bis(carbamoylcholine).
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