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Acta Physiologica Scandinavica | Vol.45, Issue.2-3 | | Pages 116-121

Influence of Some Specific Group Inhibitor on Rat Intrinsic Factor

RALPH GRÄSBECH

Abstract

Abstract. The influence of some specific group inhibitors on rat intrinsic factor was studied in order to elucidate the nature of the active structure of intrinsic factor. Iodine and fluorodinitrobenzene inhibited both the vitamin B₁₂-_-binding capacity and the physiological intrinsic factor activity, whereas p-chloromercuribenzoate and diisopropylfluorophosphate lacked effect on either activity. The results add further evidence in favor of the concept that intrinsic factor contains an essential structure which binds B₁₂, and that a phenolic group may be involved in this structure.

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Influence of Some Specific Group Inhibitor on Rat Intrinsic Factor

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Keywords

physiological intrinsic factor vitamin bsub12subsubsubbinding capacity

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RALPH GRÄSBECH,.Influence of Some Specific Group Inhibitor on Rat Intrinsic Factor. 45 (2-3),116-121.

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