Abstract Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been extensively studied, its down-stream regulators and the underlying mechanisms remain largely elusive. From a Drosophila genetic screen, we identified Snail (Sna), a Zinc-finger transcription factor, as a novel modulator of ectopic Egr-induced JNK-mediated cell death. In addition, sna is essential for the physiological function of JNK signaling in development. Our genetic epistasis data suggest that Sna acts downstream of JNK to promote cell death. Mechanistically, JNK signaling triggers dFoxO-dependent transcriptional activation of sna. Thus, our findings not only reveal a novel function and the underlying mechanism of Sna in modulating JNK-mediated cell death, but also provide a potential drug target and therapeutic strategies for JNK signaling-related diseases.

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tissue dfoxodependent transcriptional activation of sna animal development zincfinger transcription factor jnk signalingrelated diseases ectopic egrinduced jnkmediated cell death developmental and immunological disorders neurodegenerative

Chenxi Wu,Zhuojie Li,Xiang Ding,Xiaowei Guo,Ying Sun,Xingjun Wang,Yujia Hu,Tongtong Li,Xiaojin La,Jianing Li,Ji-an Li,Wenzhe Li,Lei Xue,.Snail modulates JNK-mediated cell death in Drosophila. 10 (12),.

Chenxi Wu,Zhuojie Li,Xiang Ding,Xiaowei Guo,Ying Sun,Xingjun Wang,Yujia Hu,Tongtong Li,Xiaojin La,Jianing Li,Ji-an Li,Wenzhe Li,Lei Xue,"Snail modulates JNK-mediated cell death in Drosophila" 10

Chenxi Wu,Zhuojie Li,Xiang Ding,Xiaowei Guo,Ying Sun,Xingjun Wang,Yujia Hu,Tongtong Li,Xiaojin La,Jianing Li,Ji-an Li,Wenzhe Li,Lei Xue,"Snail modulates JNK-mediated cell death in Drosophila"