Abstract Recent studies have shown that miR-494-3p is oncogene and has a central role in many solid tumors; however, the role of miR-494-3p in the progression and prognosis of hepatocellular carcinoma (HCC) remains unknown. In this study, it was found that miR-494-3p was up-regulated in HCC tissues. The high level of miR-494-3p in HCC tumors was correlated with aggressive clinicopathological characteristics and predicted poor prognosis in HCC patients. Functional study demonstrated that miR-494-3p significantly promoted HCC cell metastasis in vitro and vivo. Since phosphoinositide 3-kinase/protein kinase-B (PI3K/AKT) signaling is a basic oncogenic driver in HCC, a potential role of miR-494-3p was explored as well as its target genes in PI3K/AKT activation. Of all the predicted target genes of miR-494-3p, the tumor-suppressor phosphatase and tensin homolog (PTEN) were identified. In conclusion, the data we collected could define an original mechanism of PI3K/AKT hyperactivation and sketch the regulatory role of miR-494-3p in suppressing the expression of PTEN. Therefore, targeting miR-494-3p could provide an effective therapeutic method for the treatment of the disease.

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phosphoinositide 3kinaseprotein kinaseb pi3kakt signaling tumorsuppressor phosphatase and tensin homolog pten mir4943p expression of pten

Hui Lin,Zhi-Ping Huang,Jiao Liu,Yun Qiu,Yuan-ping Tao,Meng-chao Wang,Hui Yao,Ke-zhu Hou,Fang-ming Gu,Xuan-fu Xu,.MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN. 8 (1),.

Hui Lin,Zhi-Ping Huang,Jiao Liu,Yun Qiu,Yuan-ping Tao,Meng-chao Wang,Hui Yao,Ke-zhu Hou,Fang-ming Gu,Xuan-fu Xu,"MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN" 8

Hui Lin,Zhi-Ping Huang,Jiao Liu,Yun Qiu,Yuan-ping Tao,Meng-chao Wang,Hui Yao,Ke-zhu Hou,Fang-ming Gu,Xuan-fu Xu,"MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN"