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Nature Communications | Vol.9, Issue.1 | | Pages

BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin

Feng Wang,Qing He,Jia Yin,Sujuan Xu,Wei Hu,Lichuan Gu

Abstract

The virulence factor pyocyanin and the second messenger c-di-GMP regulate biofilm formation and antibiotic tolerance in Pseudomonas aeruginosa. Here, the authors perform structural and biochemical analyses to show that a transcriptional regulator, BrlR, acts as a receptor for both pyocyanin and c-di-GMP.

Original Text (This is the original text for your reference.)

BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin

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Keywords

antibiotic tolerance pyocyanin and cdigmp virulence factor pyocyanin transcriptional regulator brlr second messenger cdigmp biofilm formation

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Feng Wang,Qing He,Jia Yin,Sujuan Xu,Wei Hu,Lichuan Gu,.BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin. 9 (1),.

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