Osteoporosis is a disease characterized by osteoclast-mediated low bone mass. The modulation of osteoclasts is important for the prevention or therapeutic treatment of loss of bone mass. Osteoclasts, which are bone-resorbing multinucleated cells, are differentiated from the hematopoietic stem cell monocyte/macrophage lineage by Receptor activator of nuclear factor kappa-B ligand (RANKL) expressed from osteoblasts and stromal cells. RANKL signaling ultimately activates nuclear factor of activated T Cells 1 (NFATc1), which is a master transcription factor in osteoclastogenesis. Betulin, a lupine type pentacyclic triterpenoid, was isolated from the bark of Betula platyphylla. Betulin inhibited RANKL-mediated osteoclast differentiation by downregulating NFATc1. Betulin may serve as a useful structural scaffold in the therapeutic agent development to prevention/treatment the osteoclast-mediated bone disorder.

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osteoclastmediated bone disorder hematopoietic stem cell monocytemacrophage osteoclast loss of bone kappab osteoclasts transcription factor

Kwang-Jin Kim,Yongjin Lee,Hae-Gwang Hwang,Sang Hyun Sung,Mina Lee,Young-Jin Son,.Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1. 7 (6),.

Kwang-Jin Kim,Yongjin Lee,Hae-Gwang Hwang,Sang Hyun Sung,Mina Lee,Young-Jin Son,"Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1" 7

Kwang-Jin Kim,Yongjin Lee,Hae-Gwang Hwang,Sang Hyun Sung,Mina Lee,Young-Jin Son,"Betulin Suppresses Osteoclast Formation via Down-Regulating NFATc1"