Since 1990s, research and development of microneedles (MNs) for transdermal drug delivery (TDD) have been receiving great attention. Among various kinds of MNs, the dissolvable polymer MNs provide several attractive merits such as biocompatibility, biodegradability, and active and controlled release of drugs. Currently, the widely practiced approaches, i.e. evaporation and centrifugation, suffer from either relatively long processing time or tedious procedure. This project aims to develop and validate a new method, i.e. spin-coating process, to fabricate polymer MNs in a relatively simple and fast manner. First, the polydimethylsiloxane (PDMS) daughter mold replicated from the MNs array was used and bonded to the cleaned glass slide. The assembly was then placed on the spin coater, followed by dispensing the polymer solution and switching on the spin coater. It was found that, addition of trace amount of bovine serum albumin (BSA) in the polymer solution will facilitate formation of polymer film on PDMS surface by spin coating. Moreover, with the simple setup and procedures, the dissolvable polymer MNs with needle height up to 300 µm can be obtained.

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method italicieitalic spincoating process transdermal drug delivery albumin dissolvable polymer mns pdms daughter mold active and controlled release of drugs biocompatibility approaches italicieitalic evaporation coater 1990hsp polymer film on pdms surface

Min-Hsien Wu, Yi-Je Juang, I-Chi Lee,Ming-Ta Lee, Shau-Wei Tsai, Chih-Hao Chen,.Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch. 70 (0),42-48.

Min-Hsien Wu, et al."Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch" 70

Min-Hsien Wu, Yi-Je Juang, I-Chi Lee,Ming-Ta Lee, Shau-Wei Tsai, Chih-Hao Chen,"Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch"