The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were randomly divided into one of three groups; non-exercise control, Low-exercise, and High-exercise. The animals in the Low- and High-exercise groups were subjected to a 10-minute treadmill workout at 40% and 80% maximum oxygen intake intensity, respectively. In the Low-exercise groups, a significant EIH response was observed in aged but not in adult rats. The pre-treatment with ALLO synthesis inhibitor finasteride, but not opioid-receptor antagonist naloxone, inhibited the Low-exercise induced EIH response in aged rats. Furthermore, the Low-exercise increased brain ALLO levels in aged animals compared with controls, which was correlated with the mechanical pain sensitivity. On the other hand, High-exercise could induce EIH response in both adult and aged animals, but it was more effective in adult rats. The pre-treatment with naloxone, but not finasteride, reduced the EIH observed after High-exercise in both adult and aged rats. Our findings demonstrated that effective EIH can be achieved even by mild-intensity exercise in aged animals via an increase of the brain ALLO levels. Keywords: Neurosteroid, Allopregnanolone, Aging, Exercise, Acute pain

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treadmill brain allo levels keywords neurosteroid allopregnanolone aging eih response agerelated change lowexercise mechanical pain

Bun Aoyama,Takashi Kawano,Hideki Iwata,Atsushi Nishigaki,Daiki Yamanaka,Hiroki Tateiwa,Marie Shigematsu-Locatelli,Satoru Eguchi,Fabricio M. Locatelli,Masataka Yokoyama,.Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats. 139 (2),.

Bun Aoyama,Takashi Kawano,Hideki Iwata,Atsushi Nishigaki,Daiki Yamanaka,Hiroki Tateiwa,Marie Shigematsu-Locatelli,Satoru Eguchi,Fabricio M. Locatelli,Masataka Yokoyama,"Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats" 139

Bun Aoyama,Takashi Kawano,Hideki Iwata,Atsushi Nishigaki,Daiki Yamanaka,Hiroki Tateiwa,Marie Shigematsu-Locatelli,Satoru Eguchi,Fabricio M. Locatelli,Masataka Yokoyama,"Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats"