Arginine (Arg) is a conditionally-essential amino acid that is taken up by bovine mammary gland in excess of its output in milk. In this study we evaluated the effects of Arg concentration on the expression of casein and signaling pathway-related genes in mammary epithelial cells. The treatments (applied for 24 h) were designed to be devoid of Arg 0X (control; 0.00 mg/L), resemble the profile of Arg in casein (Arg 1X; 278.00 mg/L), be deficient [Arg 0.25X (69.50 mg/L) and Arg 0.5X (139.00 mg/L)], or be in excess of the amount in casein [Arg 2X (556.00 mg/L), Arg 4X (1,112 mg/L), and Arg 8X (2,224 mg/L)]. The expression of CSN1S, CSN3 and mTOR in the experimental groups was higher than those of the control group (P0.05), the expression of CSN1S2, CSN2 and JAK2 in other experimental groups was higher (P0.05), the expression of STAT5 in the other experimental groups was higher than those of the control (P

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csn1s2 csn2 csn1s csn3 jak2 casein signaling pathwayrelated genes mtor stat5

Jiaqi Wang,Dengpan Bu,Mengzhi Wang,Bolin Xu,Hongrong Wang,Juan-Jose Loor,.Effects of Arginine concentration on the in vitro expression of Casein and mTOR pathway related genes in mammary epithelial cells from dairy cattle.. 9 (5),.

Jiaqi Wang,Dengpan Bu,Mengzhi Wang,Bolin Xu,Hongrong Wang,Juan-Jose Loor,"Effects of Arginine concentration on the in vitro expression of Casein and mTOR pathway related genes in mammary epithelial cells from dairy cattle." 9

Jiaqi Wang,Dengpan Bu,Mengzhi Wang,Bolin Xu,Hongrong Wang,Juan-Jose Loor,"Effects of Arginine concentration on the in vitro expression of Casein and mTOR pathway related genes in mammary epithelial cells from dairy cattle."