BACKGROUND: Previous reports showed that outcome of rabbit antithymocyte globulin (rATG) was not satisfactory as the first-line therapy for severe aplastic anemia (SAA). We explored a modifying schedule of administration of rATG. DESIGN AND METHODS: Outcomes of a cohort of 175 SAA patients, including 51 patients administered with standard protocol (3.55 mg/kg/d for 5 days) and 124 cases with optimized protocol (1.97 mg/kg/d for 9 days) of rATG plus cyclosporine (CSA), were analyzed retrospectively. RESULTS: Of all 175 patients, response rates at 3 and 6 months were 36.6% and 56.0%, respectively. 51 cases received standard protocol had poor responses at 3 (25.5%) and 6 months (41.2%). However, 124 patients received optimized protocol had better responses at 3 (41.1%, P = 0.14) and 6 (62.1%, P = 0.01). Higher incidences of infection (57.1% versus 37.9%, P = 0.02) and early mortality (17.9% versus 0.8%, P

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Jing Zhang,Jun Shi,Jinbo Huang,Meili Ge,Xingxin Li,Yizhou Zheng,Yingqi Shao,Zhendong Huang,Neng Nie,.Outcomes of optimized over standard protocol of rabbit antithymocyte globulin for severe aplastic anemia: a single-center experience.. 8 (3),.

Jing Zhang,Jun Shi,Jinbo Huang,Meili Ge,Xingxin Li,Yizhou Zheng,Yingqi Shao,Zhendong Huang,Neng Nie,"Outcomes of optimized over standard protocol of rabbit antithymocyte globulin for severe aplastic anemia: a single-center experience." 8

Jing Zhang,Jun Shi,Jinbo Huang,Meili Ge,Xingxin Li,Yizhou Zheng,Yingqi Shao,Zhendong Huang,Neng Nie,"Outcomes of optimized over standard protocol of rabbit antithymocyte globulin for severe aplastic anemia: a single-center experience."