[11C] CO is a highly versatile synthon that allows for labeling at carbonyl positions of many molecules by means of transition metal‐mediated carbonylation reactions. The intrinsic complexity of carbonylation reactions often requires tedious screening of reaction conditions for obtaining satisfying yields. Herein, a [11C] CO dispending system for performing multiple reactions with a single batch of cyclotron‐produced [11C]CO2 is described. This semiautomated setup allows for more rapid and efficient screening of reactions and reaction conditions compared with the traditional “one beam for one reaction” strategy.

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semiautomated setup carbonyl one beam transition metalmediated carbonylation cyclotronproduced synthon co dispending system

Berend Van der Wildt, Bin Shen, Frederick T. Chin,.A [11C] CO dispensing system for rapid screening of carbonylation reactions. 61 (61),1110-1114.

Berend Van der Wildt, Bin Shen, Frederick T. Chin,"A [11C] CO dispensing system for rapid screening of carbonylation reactions" 61

Berend Van der Wildt, Bin Shen, Frederick T. Chin,"A [11C] CO dispensing system for rapid screening of carbonylation reactions"