BACKGROUND AND AIM: Circulating microRNAs (miRNAs) are potential biomarkers for cancer detection; however, little is known about their prognostic impact on oesophageal squamous cell carcinoma (ESCC). The current study aims to uncover novel miRNAs for prognostic biomarkers in ESCC patients. PATIENTS AND METHODS: We initially screened the expression of 754 serum miRNAs using TaqMan Low Density Array in two pooled samples respectively from 28 ESCC and 28 normal controls. Markedly upregulated miRNAs in ESCC and some miRNAs reported to be differently expressed in ESCC tissue were then validated individually by RT-qPCR in another 83 patients and 83 controls arranged in two phases. The changes of the selected miRNAs during the esophagectomy and their prognostic value were examined. RESULTS: Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p (P

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taqman low density array controls mir4835p p mir194 mir223 mir3375p circulating micrornas escc patients squamous cell carcinoma

Xi Chen,Cheng Wang,Xiaojun Zhou,Chen-Yu Zhang,Chunni Zhang,Demin Li,Junjun Wang,Yanni Zhang,Ke Zen,Caiyun Wu,Xiaocui Guan,Yuxiu Liu,.Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma.. 9 (3),.

Xi Chen,Cheng Wang,Xiaojun Zhou,Chen-Yu Zhang,Chunni Zhang,Demin Li,Junjun Wang,Yanni Zhang,Ke Zen,Caiyun Wu,Xiaocui Guan,Yuxiu Liu,"Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma." 9

Xi Chen,Cheng Wang,Xiaojun Zhou,Chen-Yu Zhang,Chunni Zhang,Demin Li,Junjun Wang,Yanni Zhang,Ke Zen,Caiyun Wu,Xiaocui Guan,Yuxiu Liu,"Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma."