Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arterial spin labelling (ASL) for cerebral blood flow mapping to characterise the neural correlates of perceived intensity of osteoarthritis (OA) pain and its interrelation with negative affect. Twenty-six patients with painful knee OA and twenty-seven healthy controls underwent pain phenotyping and ASL MRI at 3T. Intensity of OA pain correlated positively with blood flow in the anterior mid-cingulate cortex (aMCC), subgenual cingulate cortex (sgACC), bilateral hippocampi, bilateral amygdala, left central operculum, mid-insula, putamen and the brainstem. Additional control for trait anxiety scores reduced the pain-CBF association to the aMCC, whilst pain catastrophizing scores only explained some of the limbic correlations. In conclusion, we found that neural correlates of reported intensity of ongoing chronic pain intensity mapped to limbic-affective circuits, and that the association pattern apart from aMCC was explained by trait anxiety thus highlighting the importance of aversiveness in the experience of clinical pain.

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midinsula asl mri affect central processing of evoked pain block and eventrelated designs pain phenotyping arterial spin labelling asl limbicaffective circuits catastrophizing aversiveness midcingulate cerebral blood flow mapping neural correlates neural correlates of reported intensity of ongoing chronic pain intensity paincbf magnetic resonance imaging

William J. Cottam,Laura Condon,Hamza Alshuft,Diane Reckziegel,Dorothee P. Auer,.Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. 12 (C),.

William J. Cottam,Laura Condon,Hamza Alshuft,Diane Reckziegel,Dorothee P. Auer,"Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety" 12

William J. Cottam,Laura Condon,Hamza Alshuft,Diane Reckziegel,Dorothee P. Auer,"Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety"