To create annotated clinical narratives with layers of syntactic and semantic labels to facilitate advances in clinical natural language processing (NLP). To develop NLP algorithms and open source components.Manual annotation of a clinical narrative corpus of 127 606 tokens following the Treebank schema for syntactic information, PropBank schema for predicate-argument structures, and the Unified Medical Language System (UMLS) schema for semantic information. NLP components were developed.The final corpus consists of 13 091 sentences containing 1772 distinct predicate lemmas. Of the 766 newly created PropBank frames, 74 are verbs. There are 28 539 named entity (NE) annotations spread over 15 UMLS semantic groups, one UMLS semantic type, and the Person semantic category. The most frequent annotations belong to the UMLS semantic groups of Procedures (15.71%), Disorders (14.74%), Concepts and Ideas (15.10%), Anatomy (12.80%), Chemicals and Drugs (7.49%), and the UMLS semantic type of Sign or Symptom (12.46%). Inter-annotator agreement results: Treebank (0.926), PropBank (0.891-0.931), NE (0.697-0.750). The part-of-speech tagger, constituency parser, dependency parser, and semantic role labeler are built from the corpus and released open source. A significant limitation uncovered by this project is the need for the NLP community to develop a widely agreed-upon schema for the annotation of clinical concepts and their relations.This project takes a foundational step towards bringing the field of clinical NLP up to par with NLP in the general domain. The corpus creation and NLP components provide a resource for research and application development that would have been previously impossible.

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disorders syntactic and semantic labels procedures clinical narrative corpus anatomy symptom nlp algorithms interannotator agreement results treebank 0926 propbank 08910931 ne syntactic information partofspeech tagger constituency parser dependency parser sign predicateargument schema named entity ne source unified medical language system umls semantic role labeler annotated clinical narratives annotation of clinical concepts chemicals clinical natural language processing

Daniel, Albright Arrick, Lanfranchi Anwen, Fredriksen William F, Styler Colin, Warner Jena D, Hwang Jinho D, Choi Dmitriy, Dligach Rodney D, Nielsen James, Martin Wayne, Ward Martha, Palmer Guergana K, Savova,.Towards comprehensive syntactic and semantic annotations of the clinical narrative.. 20 (5),922-30.

Daniel, Albright Arrick, Lanfranchi Anwen, Fredriksen William F, Styler Colin, Warner Jena D, Hwang Jinho D, Choi Dmitriy, Dligach Rodney D, Nielsen James, Martin Wayne, Ward Martha, Palmer Guergana K, Savova,"Towards comprehensive syntactic and semantic annotations of the clinical narrative." 20

Daniel, Albright Arrick, Lanfranchi Anwen, Fredriksen William F, Styler Colin, Warner Jena D, Hwang Jinho D, Choi Dmitriy, Dligach Rodney D, Nielsen James, Martin Wayne, Ward Martha, Palmer Guergana K, Savova,"Towards comprehensive syntactic and semantic annotations of the clinical narrative."