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Eksperimental'naia i klinicheskaia farmakologiia | Vol.62, Issue.4 | | Pages 65-6

[The effect of polikatan on the ototoxic action of kanamycin].

A A, Spasov M S, Lobzov N K, Sanzharovskaia E V, Kozhevnikova E A, Kuzubova

Abstract

Experiments on guinea pigs demonstrated that preliminary injection of polycatan (standardized magnesium solution containing the mineral bischofite) into the parotid region by means of electrophoresis reduces the ototoxic effect of the aminoglycoside antibiotic kanamycin. Polycatan prevents kanamycin-induced degenerative changes of the hair cells found in the labyrinth of the internal ear and improves the local blood flow.

Original Text (This is the original text for your reference.)

[The effect of polikatan on the ototoxic action of kanamycin].

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Keywords

parotid region aminoglycoside antibiotic ototoxic hair cells labyrinth local blood flow electrophoresis degenerative changes

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A A, Spasov M S, Lobzov N K, Sanzharovskaia E V, Kozhevnikova E A, Kuzubova,.[The effect of polikatan on the ototoxic action of kanamycin].. 62 (4),65-6.

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