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Ukrainski? biokhimicheski? zhurnal (1978) | Vol.51, Issue.4 | | Pages 382-6

[Application of immobilized animal liver microsomal fraction to the reaction of 1,4-benzdiazepine-2-one conversion].

A V, Bogatski? T I, Davidenko O V, Sevast'ianov

Abstract

The albino rat strain Wistar and Shynashylla rabbit liver microsomal fraction was immobilized by incorporation into polyacrylamide gel. It is shown, that the microsomal fraction immobilized by such a method catalyzes the hydrolysis of 1,4-benzdiazepine-2 ones, 3-acetoxyderivatives, hydroxylation in position 3 of 1,4-benzdiazepine-2-ones and reduction of nitrazepame. The storage thermostability and stability of the immobilized preparations were studied. Immobilization of the animal liver microsomal fraction was conducted on sylochrome by cyanuric chloride and 2,4-toluylenediisocyanate.

Original Text (This is the original text for your reference.)

[Application of immobilized animal liver microsomal fraction to the reaction of 1,4-benzdiazepine-2-one conversion].

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Keywords

ones 3acetoxyderivatives

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A V, Bogatski? T I, Davidenko O V, Sevast'ianov,.[Application of immobilized animal liver microsomal fraction to the reaction of 1,4-benzdiazepine-2-one conversion].. 51 (4),382-6.

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