To overcome differences in the choice of collimator for an iodine-123 ((123)I)-labeled meta-iodobenzylguanidine (MIBG) heart-to-mediastinum (H/M) ratio, we examined multi-window correction methods with (123)I dual-window (IDW) and triple-energy window (TEW) acquisition.Standard phantoms, which consisted of the heart, mediastinum, lung, and liver, were generated. Three correction methods were compared: TEW and two IDW methods (IDW(0) and IDW(1)). Low-energy high-resolution (LEHR), medium-energy (ME), and (123)I-specific low-medium-energy high-resolution (LMEHR) collimators were used. Clinical studies were performed in 10 patients. In the phantom study, the H/M ratio was significantly underestimated without correction, with both the LEHR and ME collimators (70% and 88% of the true value). When H/M with the LEHR collimator was divided by uncorrected H/M with the ME collimator, the ratio (mean +/- SD) was 80% +/- 5%, 98% +/- 5%, 104% +/- 7%, and 98% +/- 5% for the no-correction, TEW, IDW(0), and IDW(1) methods, respectively. Clinical studies with the LEHR collimator after TEW and IDW correction (uncorrected average H/M ratio, 1.86 +/- 0.23; TEW, 2.47 +/- 0.46, P = .0015; IDW, 2.46 +/- 0.46, P = .0017) provided comparable values to the uncorrected ME collimator (2.56 +/- 0.46, P = NS vs TEW and IDW).The H/M ratio with the ME collimator, after application of the TEW or IDW methods, was close to the theoretical value in the phantom study. However, the corrected H/M ratios with the LEHR collimator provided comparable H/M ratios to the uncorrected ME data in phantom and clinical studies.

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clinical studies tew idw0 123i dualwindow idw and tripleenergy window tew acquisitionstandard lehr and me collimators 70 hm ratio 186 mean 123ispecific lowmediumenergy highresolution lmehr multiwindow correction methods value iodine123 123ilabeled metaiodobenzylguanidine mibg hearttomediastinum hm

Kenichi, Nakajima Kosuke, Matsubara Takehiro, Ishikawa Nobutoku, Motomura Ryo, Maeda Nasima, Akhter Koichi, Okuda Junichi, Taki Seigo, Kinuya,.Correction of iodine-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart-to-mediastinum ratio.. 14 (6),843-51.

Kenichi, Nakajima Kosuke, Matsubara Takehiro, Ishikawa Nobutoku, Motomura Ryo, Maeda Nasima, Akhter Koichi, Okuda Junichi, Taki Seigo, Kinuya,"Correction of iodine-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart-to-mediastinum ratio." 14

Kenichi, Nakajima Kosuke, Matsubara Takehiro, Ishikawa Nobutoku, Motomura Ryo, Maeda Nasima, Akhter Koichi, Okuda Junichi, Taki Seigo, Kinuya,"Correction of iodine-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart-to-mediastinum ratio."