The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.

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analytic methodologies nonmsderived pattern data analysis pipeline hybrid strategy highinformation content ms pattern biomarker discovery and clinical diagnosis

Michael A, Gillette D R, Mani Steven A, Carr,.Place of pattern in proteomic biomarker discovery.. 4 (4),1143-54.

Michael A, Gillette D R, Mani Steven A, Carr,"Place of pattern in proteomic biomarker discovery." 4

Michael A, Gillette D R, Mani Steven A, Carr,"Place of pattern in proteomic biomarker discovery."