Neurological disturbances due to lithium-carbamazepine combination therapy are infrequent, and only a few cases have been reported so far. We describe a most unusual case of a patient with a history of bipolar disorder who developed ataxic gait, imbalance, and intention tremor after lithium-and-carbamazepine combination treatment with therapeutic serum levels of both drugs; he recovered completely when carbamazepine was discontinued. We also review the literature about this infrequent relationship, discuss on its proposed origin, and underline its importance as a potential adverse effect in elderly patients, yet with therapeutic or even subtherapeutic serum levels.

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disturbances serum levels ataxic gait imbalance lithiumcarbamazepine combination therapy intention tremor

Jose-Alberto, Palma Roberto, Fernandez-Torron Jaime, Gallego Perez-Larraya,.Extrapyramidal syndrome related to lithium-carbamazepine combination therapy at therapeutic serum levels.. 33 (2),102-3.

Jose-Alberto, Palma Roberto, Fernandez-Torron Jaime, Gallego Perez-Larraya,"Extrapyramidal syndrome related to lithium-carbamazepine combination therapy at therapeutic serum levels." 33

Jose-Alberto, Palma Roberto, Fernandez-Torron Jaime, Gallego Perez-Larraya,"Extrapyramidal syndrome related to lithium-carbamazepine combination therapy at therapeutic serum levels."