Cancer metastases are commonly found in the lymphatic system and tumor lymphangiogenesis requires the interplay of several growth factors. The expression of platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C in esophageal cancer was investigated to define their clinicopathological significance.Using immunohistochemistry, the expression of PDGF-BB and VEGF-C was examined, along with lymphatic vessel density (LVD) in 53 patients with esophageal cancer.PDGF-BB and VEGF-C expression was positive in 31 cases (58.5%) and 38 cases (71.7%), respectively, and expression correlated with lymph node metastasis and lymphatic invasion. Furthermore, PDGF-BB expression correlated with the depth of tumor invasion and the size of the tumor, and PDGF-BB-positive patients had a significantly poorer prognosis than PDGF-BB-negative patients. The LVD in positive PDGF-BB or VEGF-C tumors was higher than in negative tumors.PDGF-BB may play a pivotal role in lymphangiogenesis and tumor growth in esophageal cancer.

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invasion lymphangiogenesis and tumor growth cancerpdgfbb vegfc vascular endothelial growth factor lymphatic vessel density pdgfbb

Sohei, Matsumoto Yukishige, Yamada Michihiro, Narikiyo Masato, Ueno Hidetoshi, Tamaki Katsuhiko, Miki Kohei, Wakatsuki Koji, Enomoto Tomoyo, Yokotani Yoshiyuki, Nakajima,.Prognostic significance of platelet-derived growth factor-BB expression in human esophageal squamous cell carcinomas.. 27 (4B),2409-14.

Sohei, Matsumoto Yukishige, Yamada Michihiro, Narikiyo Masato, Ueno Hidetoshi, Tamaki Katsuhiko, Miki Kohei, Wakatsuki Koji, Enomoto Tomoyo, Yokotani Yoshiyuki, Nakajima,"Prognostic significance of platelet-derived growth factor-BB expression in human esophageal squamous cell carcinomas." 27

Sohei, Matsumoto Yukishige, Yamada Michihiro, Narikiyo Masato, Ueno Hidetoshi, Tamaki Katsuhiko, Miki Kohei, Wakatsuki Koji, Enomoto Tomoyo, Yokotani Yoshiyuki, Nakajima,"Prognostic significance of platelet-derived growth factor-BB expression in human esophageal squamous cell carcinomas."