Functional uterine bleeding may occur when a corpus luteum is present in the ovary. The endometrium in some instances may evidence irregular regression (Specimens 335, 332, 334, 293, and 265). The irregular regression is the result of prolonged life and function of the corpus luteum. The endometrial picture will vary, depending upon the rate and extent of regression of the corpus luteum. The bleeding which occurs seems to be an exaggeration of the normal bleeding processes observed in cyclic menstruation. The corpus luteum in other instances may be histologically and functionally normal. The endometrium, except in small regions, responds normally. It is from these small regions that bleeding occurs. The bleeding in these instances is independent of the corpus luteum and of the remainder of the endometrium. The bleeding is unlike the usual normal menstrual bleeding. It is localized bleeding from blood sinuses with scant loss of endometrial tissues. During this type of bleeding ovulation can occur, corpus luteum development can progress normally, and the endometrium not involved in the bleeding can develop normally. (Specimens 257, 266, 273). The phenomena that occur that produce the bleeding in such instances are not known. The explanation may reside in a local bleeding factor in the endometrium or in the local abnormality of response of the endometrium.

+More

bleeding factor

John I. Brewer Harold O. Jones,.Studies of the human corpus luteum: Corpus luteum-endometrial relationships in functional uterine bleeding. 55 (1),18-45.

John I. Brewer Harold O. Jones,"Studies of the human corpus luteum: Corpus luteum-endometrial relationships in functional uterine bleeding" 55

John I. Brewer Harold O. Jones,"Studies of the human corpus luteum: Corpus luteum-endometrial relationships in functional uterine bleeding"