Microscale hollow Mg-doped calcium carbonate was fabricated using yeast cell as biotemplate. The yeasts pre-adsorbed magnesium metabolically due to special biosorption for metallic ions. Vaterite was preferably formed rather than calcite during the fabrication in which yeast biotemplate with high Mg²⁺ content was used, and a larger amount of magnesium was also doped within. When being co-cultured with mouse mesenchymal stem cells, the vaterite/calcite composite microcapsules with high Mg content revealed a better cytocompatibility than the calcite microcapsules without Mg or with less Mg content. This study is expected to promote the development of novel biomimetic materials.

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hollow mgdoped calcium carbonate metallic ions mesenchymal stem biomimetic materials vateritecalcite composite

Tianjie Li, Chang Du, Yingjun Wang, Lijing Hao,.Synthesis of magnesium-doped calcium carbonate microcapsules through yeast-regulated mineralization. 193 (0),38-41.

Tianjie Li, et al."Synthesis of magnesium-doped calcium carbonate microcapsules through yeast-regulated mineralization" 193

Tianjie Li, Chang Du, Yingjun Wang, Lijing Hao,"Synthesis of magnesium-doped calcium carbonate microcapsules through yeast-regulated mineralization"